The intensive research is implemented within the ophthalmic drug delivery system to attain the far better drug products. For the treatment of eye alignment one amongst the foremost promising route of drug delivery is ophthalmic route. Within the modern pharmaceutical design controlled and sustained drug delivery has become the standard in order to overcome the problem related with the conventional eye drops. Within the sustained and controlled ophthalmic in-situ gelling system the quantity of the drug administered would be minimal and prolong the drug release by increasing the pre corneal retention time and their by increases the bioaccumulation. This work is focused on the establishment of the pH triggering ophthalmic in-situ gelling system of azithromycin by using mixture of polymers such as carbopol 934 as pH triggering polymer and guar gum as the viscosity enhancing agent all this polymers are utilized in distinct proportion together with the preservative benzalkonium chloride. The advance pH triggering in-situ gelling system are subjected for several evaluation test where the advance formulation show the sustained drug release over a period of 24 hours and establish to be sterile and nonirritant in nature.
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